Trim58^tm2313.2Arte
Targeted Allele Detail

Summary

• Symbol: Trim58^tm2313.2Arte
• Name: tripartite motif-containing 58; targeted mutation 2313.2, TaconicArtemis
• MGI ID: MGI:6362942
• Gene: Trim58 Location: Chr11:58531291-58543230 bp, + strand Genetic Position: Chr11, 36.23 cM
• Alliance: Trim58^tm2313.2Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279270
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3-5 were flanked by loxP sites and a FRT-flanked neomycin resistance gene and F3-flanked puromycin resistance gene were inserted into intron 2 and intron 5, respectively. Flp-mediated recombination removed the selection makers and cre-mediated recombination removed exons 3-5, generating a frameshift from exons 2 to 6 and a premature stop codon in exon 6. (J:279270)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim58 Mutation: 24 strains or lines available

References

• Original: J:279270 Eyking A, et al., TRIM58 Restrains Intestinal Mucosal Inflammation by Negatively Regulating TLR2 in Myeloid Cells. J Immunol. 2019 Sep 15;203(6):1636-1649
• All: 1 reference(s)