Plekho2^em1Lzhn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Plekho2^em1Lzhn
• Name: pleckstrin homology domain containing, family O member 2; endonuclease-mediated mutation 1, Luo Zhang
• MGI ID: MGI:6363012
• Gene: Plekho2 Location: Chr9:65459980-65487322 bp, - strand Genetic Position: Chr9, 35.38 cM
• Alliance: Plekho2^em1Lzhn page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN-targeting exon 2 deleted 13 bp at the 132nd bp downstream of the ATG stranscription-start site that truncates the protein after Val55. Western blot analysis confirmed the absence of protein expression in heart, lung and brain. (J:270531)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plekho2 Mutation: 19 strains or lines available

References

• Original: J:270531 Zhang P, et al., PLEKHO2 is essential for M-CSF-dependent macrophage survival. Cell Signal. 2017 Sep;37:115-122
• All: 1 reference(s)