Mir185^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mir185^em1Smoc
• Name: microRNA 185; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6363070
• Gene: Mir185 Location: Chr16:18145265-18145329 bp, - strand Genetic Position: Chr16, 11.35 cM
• Alliance: Mir185^em1Smoc page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 104bp deletion, which contains the entire precursor-miR-185 encoding sequence, was deleted by CRISPR/Cas9 genome editing technology. The deleted sequence lies within intron 1 of the overlapping Tango2 gene; however, real-time PCR analysis indicated that Tango2 expression in homozygous mutant mice was unaffected. (J:278853)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir185 Mutation: 3 strains or lines available

References

• Original: J:278853 Cui Q, et al., Mmu-miR-185 depletion promotes osteogenic differentiation and suppresses bone loss in osteoporosis through the Bgn-mediated BMP/Smad pathway. Cell Death Dis. 2019 Feb 20;10(3):172
• All: 1 reference(s)