Pbxip1^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pbxip1^em1Smoc
• Name: pre B cell leukemia transcription factor interacting protein 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6363078
• Gene: Pbxip1 Location: Chr3:89344013-89358259 bp, + strand Genetic Position: Chr3, 39.12 cM
• Alliance: Pbxip1^em1Smoc page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 3 (guide RNA sequence isTGGAGGAGTCCCGAAGGGCCTGG) deleted the sequence encoding amino acids 225 to 247. (J:270267)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pbxip1 Mutation: 30 strains or lines available

References

• Original: J:270267 Ji Q, et al., Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis. Nat Commun. 2019 Jan 18;10(1):313
• All: 1 reference(s)