Rpl5^tm1Itl
Targeted Allele Detail

Summary

• Symbol: Rpl5^tm1Itl
• Name: ribosomal protein L5; targeted mutation 1, inGenious Targeting Laboratory
• MGI ID: MGI:6363222
• Gene: Rpl5 Location: Chr5:108048388-108056871 bp, + strand
• Alliance: Rpl5^tm1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278789
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A floxed neomycin resistance cassette replaced exons 1 through 8. (J:278789)

Tumor Data

List all tumor models in MMHCdb carrying Rpl5^tm1Itl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rpl5 Mutation: 14 strains or lines available

Notes

Mice heterozygous for this allele fail to develop anemia unlike Diamon-Blackfan anemia patients but do develop sarcoma (at a rate that is not statistically significant). J:278799

References

• Original: J:278789 Kazerounian S, et al., Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice. J Cancer. 2016;7(1):32-6
• All: 1 reference(s)