Cdhr2^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Cdhr2^{tm1c(EUCOMM)Hmgu}
• Name: cadherin-related family member 2; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:6363535
• Synonyms: CDHR2^tm1c
• Gene: Cdhr2 Location: Chr13:54849276-54884475 bp, + strand Genetic Position: Chr13, 29.03 cM
• Alliance: Cdhr2^{tm1c(EUCOMM)Hmgu} page
• IMPC: Cdhr2 gene page

Mutation origin

• Mutant Cell Line: HEPD0749_5_F10
• Germline Transmission: Earliest citation of germline transmission: J:273165
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: Flp-mediated recombination of the parental Cdhr2^{tm1a(EUCOMM)Hmgu} allele resulted in the removal of lacZ reporter sequence and the neomycin selection cassette, leaving exon 4-5 floxed. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:273165)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdhr2 Mutation: 61 strains or lines available

References

• Original: J:273165 Pinette JA, et al., Brush border protocadherin CDHR2 promotes the elongation and maximized packing of microvilli in vivo. Mol Biol Cell. 2019 Jan 1;30(1):108-118
• All: 1 reference(s)