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Pianpem1Bet
Endonuclease-mediated Allele Detail
Summary
Symbol: Pianpem1Bet
Name: PILR alpha associated neural protein; endonuclease-mediated mutation 1, Bernhard Bettler
MGI ID: MGI:6363553
Gene: Pianp  Location: Chr6:124973683-124980059 bp, + strand  Genetic Position: Chr6, 59.17 cM
Alliance: Pianpem1Bet page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR targeting altered the targeting sequence 5'-GACCCCACACTATAGCCCAAGGG-3' to 5'-GACCCCACACTATAGGTGTGAGATGGG-3' and resulted in a frame shift after P97 and premature termination of translation. (J:276486)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pianp Mutation:  13 strains or lines available
References
Original:  J:276486 Dinamarca MC, et al., Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing. Nat Commun. 2019 Mar 22;10(1):1331
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory