Ss18^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ss18^em1(IMPC)J
• Name: SS18, subunit of BAF chromatin remodeling complex; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6363562
• Gene: Ss18 Location: Chr18:14757255-14815971 bp, - strand Genetic Position: Chr18, 8.14 cM, cytoband B1
• Alliance: Ss18^em1(IMPC)J page
• IMPC: Ss18 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences GCTCTTGGTCTTGGGTCTTG and TCTTTGCAGTGTCGTGTTCA, which resulted in a 244 bp deletion beginning at Chromosome 18 position 14,679,354 bp and ending after 14,679,597 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000282373 (exon 2) and 167 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 23 and early truncation 18 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ss18 Mutation: 40 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)