Phldb2^tm1Msat
Targeted Allele Detail

Summary

• Symbol: Phldb2^tm1Msat
• Name: pleckstrin homology like domain, family B, member 2; targeted mutation 1, Makoto Sato
• MGI ID: MGI:6364613
• Synonyms: Phldb2^exon2-neo
• Gene: Phldb2 Location: Chr16:45566606-45773961 bp, - strand Genetic Position: Chr16, 30.08 cM
• Alliance: Phldb2^tm1Msat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:275597
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutation: Insertion
• Exon 2 was replaced by a floxed exon 2 and neomycin resistance cassette. (J:275597)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Phldb2 Mutation: 66 strains or lines available

References

• Original: J:275597 Xie MJ, et al., PIP3-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover. Sci Rep. 2019 Mar 13;9(1):4305
• All: 1 reference(s)