Caskin1^tm1.1Tayk
Targeted Allele Detail

Summary

• Symbol: Caskin1^tm1.1Tayk
• Name: CASK interacting protein 1; targeted mutation 1.1, Tayo Katano
• MGI ID: MGI:6364869
• Gene: Caskin1 Location: Chr17:24707575-24727645 bp, + strand Genetic Position: Chr17, 12.4 cM, cytoband A3.3
• Alliance: Caskin1^tm1.1Tayk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279657
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and PGK-neo cassette were inserted into intron 1 and a second loxP site was inserted in intron 6. Cre-mediated recombination deleted exons 2-6 and the PGK-neo cassette. Western blot analysis confirmed absence of protein in the spinal dorsal horn and hippocampus. (J:279657)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Caskin1 Mutation: 62 strains or lines available

References

• Original: J:279657 Katano T, et al., Distribution of Caskin1 protein and phenotypic characterization of its knockout mice using a comprehensive behavioral test battery. Mol Brain. 2018 Oct 25;11(1):63
• All: 1 reference(s)