Ociad1^tm1.1Msin
Targeted Allele Detail

Summary

• Symbol: Ociad1^tm1.1Msin
• Name: OCIA domain containing 1; targeted mutation 1.1, Maneesha S Inamdar
• MGI ID: MGI:6367551
• Gene: Ociad1 Location: Chr5:73450127-73471412 bp, + strand Genetic Position: Chr5, 38.44 cM
• Alliance: Ociad1^tm1.1Msin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279239
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 6 and a loxP site was inserted downstream of exon 6 via homologous recombination. Cre mediated recombination removed exon 6. (J:279239)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ociad1 Mutation: 31 strains or lines available

References

• Original: J:279239 Sinha S, et al., Asrij/OCIAD1 suppresses CSN5-mediated p53 degradation and maintains mouse hematopoietic stem cell quiescence. Blood. 2019 May 30;133(22):2385-2400
• All: 1 reference(s)