Mirc29tm1.1Wtsi
Targeted Allele Detail
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Symbol: |
Mirc29tm1.1Wtsi |
Name: |
microRNA cluster 29, including Mir29b-2 through Mir29c; targeted mutation 1.1, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:6367595 |
Synonyms: |
miR-29b2/c- |
Gene: |
Mirc29 Location: Chr1:194719348-194719942 bp Genetic Position: Chr1, Syntenic
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Germline Transmission: |
Earliest citation of germline transmission:
J:267719
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Parent Cell Line: |
JM8A3 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
Sanger miRNA knockouts
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intergenic deletion
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Mutation details: Mir29b2 and Mir29c in this microRNA cluster were replaced via homologous recombination with a puromycin/thymidine kinase fusion gene under the control of EM7/PGK promoters. The inserted selection cassette was flanked by loxP and F3/FRT sites. Cre-mediated recombination excised the replacement cassette.
(J:174268, J:267719)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mirc29 Mutation: |
1 strain or line available
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Original: |
J:174268 Prosser HM, et al., A resource of vectors and ES cells for targeted deletion of microRNAs in mice. Nat Biotechnol. 2011 Aug 7;29(9):840-5 |
All: |
2 reference(s) |
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