Pdxp^tm1.1Ango
Targeted Allele Detail

Summary

• Symbol: Pdxp^tm1.1Ango
• Name: pyridoxal (pyridoxine, vitamin B6) phosphatase; targeted mutation 1.1, Antje Gohla
• MGI ID: MGI:6367624
• Synonyms: Pdxp^flx, Pdxp^tm1Goh
• Gene: Pdxp Location: Chr15:78798119-78803717 bp, + strand Genetic Position: Chr15, 37.7 cM
• Alliance: Pdxp^tm1.1Ango page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270551
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a FRT-flanked PGK-neomycin resistance cassette and a second loxP site were inserted downstream of exon 1. Flp-mediated recombination removed the neomycin resistance cassette, leaving exon 1 floxed. (J:270551)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdxp Mutation: 4 strains or lines available

References

• Original: J:270551 Jeanclos E, et al., Improved cognition, mild anxiety-like behavior and decreased motor performance in pyridoxal phosphatase-deficient mice. Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):193-205
• All: 1 reference(s)