Ppp1r3g^tm1Nju
Targeted Allele Detail

Summary

• Symbol: Ppp1r3g^tm1Nju
• Name: protein phosphatase 1, regulatory subunit 3G; targeted mutation 1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:6367634
• Synonyms: PP1R3G^-
• Gene: Ppp1r3g Location: Chr13:36142822-36154371 bp, + strand Genetic Position: Chr13, 14.44 cM
• Alliance: Ppp1r3g^tm1Nju page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:249135
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2 was replaced by a PGK-neomycin cassette. Immunoblot analysis confirmed the complete absence of protein expression in the brain of homozygous mutant mice. No protein expression was detected in the liver of homozygous mutant mice upon fasting. (J:249135)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp1r3g Mutation: 12 strains or lines available

References

• Original: J:249135 Zhang Y, et al., Ablation of PPP1R3G reduces glycogen deposition and mitigates high-fat diet induced obesity. Mol Cell Endocrinol. 2017 Jan 5;439:133-140
• All: 1 reference(s)