Prcd^tm1Vya
Targeted Allele Detail

Summary

• Symbol: Prcd^tm1Vya
• Name: photoreceptor disc component; targeted mutation 1, Vadim Y Arshavsky
• MGI ID: MGI:6367736
• Synonyms: Prcd^-
• Gene: Prcd Location: Chr11:116544603-116559224 bp, + strand Genetic Position: Chr11, 81.46 cM
• Alliance: Prcd^tm1Vya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276708
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced exons 1-3, encompassing the entire protein coding sequence of the gene. Western blot and immunostaining experiments confirmed the absence of protein expression in homozygous mutant retinas. (J:276708)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prcd Mutation: 8 strains or lines available

References

• Original: J:276708 Spencer WJ, et al., PRCD is essential for high-fidelity photoreceptor disc formation. Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13087-13096
• All: 2 reference(s)