Ccl28^tm1Takna
Targeted Allele Detail

Summary

• Symbol: Ccl28^tm1Takna
• Name: C-C motif chemokine ligand 28; targeted mutation 1, Takashi Nakayama
• MGI ID: MGI:6367826
• Gene: Ccl28 Location: Chr13:120085355-120115895 bp, + strand Genetic Position: Chr13, Syntenic
• Alliance: Ccl28^tm1Takna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256896
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: Exon 1 was replaced with a gene cassette encoding enhanced GFP and the neomycin resistance gene. RT-PCR confirmed absence of mRNA in mucosal tissues. EGFP expression is undetectable in mucosal tissues. (J:256896)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccl28 Mutation: 8 strains or lines available

References

• Original: J:256896 Matsuo K, et al., CCL28-Deficient Mice Have Reduced IgA Antibody-Secreting Cells and an Altered Microbiota in the Colon. J Immunol. 2018 Jan 15;200(2):800-809
• All: 1 reference(s)