Smarcd3^tm1.2Bbr
Targeted Allele Detail

Summary

• Symbol: Smarcd3^tm1.2Bbr
• Name: SWI/SNF related BAF chromatin remodeling complex subunit D3; targeted mutation 1.2, Benoit G Bruneau
• MGI ID: MGI:6368007
• Synonyms: Baf60c^-
• Gene: Smarcd3 Location: Chr5:24797620-24829649 bp, - strand Genetic Position: Chr5, 11.93 cM, cytoband A3
• Alliance: Smarcd3^tm1.2Bbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257963
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-4 were flanked by loxP sites and a FRT-flanked neomycin resistance gene was inserted upstream of exon 1. Flp-mediated recombination removed the selection cassette and cre-mediated recombination deleted exons 1-4. (J:257963)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smarcd3 Mutation: 25 strains or lines available

References

• Original: J:257963 Sun X, et al., Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function. Biol Open. 2018 Jan 5;7(1):bio029512
• All: 1 reference(s)