Wdr91^tm1.1Bcgen
Targeted Allele Detail

Summary

• Symbol: Wdr91^tm1.1Bcgen
• Name: WD repeat domain 91; targeted mutation 1.1, Biocytogen LLC
• MGI ID: MGI:6368012
• Gene: Wdr91 Location: Chr6:34857361-34887766 bp, - strand Genetic Position: Chr6, 15.19 cM
• Alliance: Wdr91^tm1.1Bcgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247712
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A nucleus-localized beta-galactosidase gene and floxed neomycin resistance cassette replaced exons 2 through 6. Cre-mediated recombination removed the selection cassette. (J:247712)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Wdr91^tm1.1Bcgen/Wdr91^tm1.1Bcgen	Not Specified

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
cardiovascular system	√
internal hemorrhage	√
mortality/aging	√
neonatal lethality, complete penetrance	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wdr91 Mutation: 30 strains or lines available

References

• Original: J:247712 Liu K, et al., WDR91 is a Rab7 effector required for neuronal development. J Cell Biol. 2017 Oct 02;216(10):3307-3321
• All: 2 reference(s)