Porcn^tm1.2Lcm
Targeted Allele Detail

Summary

• Symbol: Porcn^tm1.2Lcm
• Name: porcupine O-acyltransferase; targeted mutation 1.2, Lewis Murtaugh
• MGI ID: MGI:6368150
• Synonyms: Porcn^delta
• Gene: Porcn Location: ChrX:8060087-8072764 bp, - strand Genetic Position: ChrX, 3.7 cM
• Alliance: Porcn^tm1.2Lcm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218165
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were introduced into the first and third introns. Flp-mediated recombination removed the FRT-flanked neo cassette inserted into the first intron. Cre-mediated recombination removed exons 2 -3. (J:218165)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Porcn Mutation: 18 strains or lines available

References

• Original: J:218165 Bankhead EJ, et al., Multiple requirements of the focal dermal hypoplasia gene porcupine during ocular morphogenesis. Am J Pathol. 2015 Jan;185(1):197-213
• All: 1 reference(s)