Myrip^tm1Tiz
Targeted Allele Detail

Summary

• Symbol: Myrip^tm1Tiz
• Name: myosin VIIA and Rab interacting protein; targeted mutation 1, Tetsuro Izumi
• MGI ID: MGI:6368190
• Gene: Myrip Location: Chr9:120132996-120305167 bp, + strand Genetic Position: Chr9, 71.5 cM
• Alliance: Myrip^tm1Tiz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258210
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 4 was disrupted by insertion of a loxP-flanked neomycin resistance gene under the PGK promoter into the exon. Western blot analysis confirmed absence of protein. (J:258210)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myrip Mutation: 39 strains or lines available

References

• Original: J:258210 Fan F, et al., Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa. Elife. 2017 Jul 4;6:e26174
• All: 2 reference(s)