Nt5c1a^tm1.1Mhrd
Targeted Allele Detail

Summary

• Symbol: Nt5c1a^tm1.1Mhrd
• Name: 5'-nucleotidase, cytosolic IA; targeted mutation 1.1, Mark H Rider
• MGI ID: MGI:6368538
• Gene: Nt5c1a Location: Chr4:123095297-123110068 bp, + strand Genetic Position: Chr4, 57.4 cM
• Alliance: Nt5c1a^tm1.1Mhrd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:245800
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT and loxP-flanked self-excising neomycin resistance cassette was inserted downstream of exon 4. Cre-mediated recombination removed exons 2 through 4 and the selection cassette. (J:245800)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nt5c1a Mutation: 19 strains or lines available

Notes

ES cells - PRX (exact line not specified)

References

• Original: J:245800 Kviklyte S, et al., Effects of genetic deletion of soluble 5'-nucleotidases NT5C1A and NT5C2 on AMPK activation and nucleotide levels in contracting mouse skeletal muscles. Am J Physiol Endocrinol Metab. 2017 Jul 1;313(1):E48-E62
• All: 1 reference(s)