Bcap31^tm1.1Bwang
Targeted Allele Detail

Summary

• Symbol: Bcap31^tm1.1Bwang
• Name: B cell receptor associated protein 31; targeted mutation 1.1, Bing Wang
• MGI ID: MGI:6368552
• Synonyms: BAP31^f, BAP31^flox
• Gene: Bcap31 Location: ChrX:72729784-72759781 bp, - strand Genetic Position: ChrX, 37.38 cM, cytoband A6
• Alliance: Bcap31^tm1.1Bwang page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:255502
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neo cassette with a 3' loxP site were inserted downstream of exon 3. Flp-mediated recombination removed the FRT-flanked neo cassette and left exon 3 floxed. (J:255502)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcap31 Mutation: 8 strains or lines available

References

• Original: J:255502 Xu JL, et al., Hepatocyte-specific deletion of BAP31 promotes SREBP1C activation, promotes hepatic lipid accumulation, and worsens IR in mice. J Lipid Res. 2018 Jan;59(1):35-47
• All: 6 reference(s)