Trim40^em1Caox
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trim40^em1Caox
• Name: tripartite motif-containing 40; endonuclease-mediated mutation 1, Xuetao Cao
• MGI ID: MGI:6368568
• Synonyms: Trim40^-
• Gene: Trim40 Location: Chr17:37192490-37201015 bp, - strand Genetic Position: Chr17, 19.16 cM
• Alliance: Trim40^em1Caox page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9-targeting removed 1,438 base pairs containing the exon 2 of Trim40 gene causing a frameshift. (J:255265)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim40 Mutation: 14 strains or lines available

References

• Original: J:255265 Zhao C, et al., The E3 Ubiquitin Ligase TRIM40 Attenuates Antiviral Immune Responses by Targeting MDA5 and RIG-I. Cell Rep. 2017 Nov 7;21(6):1613-1623
• All: 1 reference(s)