Cars2^em1Akai
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cars2^em1Akai
• Name: cysteinyl-tRNA synthetase 2, mitochondrial; endonuclease-mediated mutation 1, Takaaki Akaike
• MGI ID: MGI:6368616
• Synonyms: Cars2^- line 1
• Gene: Cars2 Location: Chr8:11564017-11600781 bp, - strand Genetic Position: Chr8, 5.73 cM, cytoband A2
• Alliance: Cars2^em1Akai page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 mediated mutagenesis created a 200-bp deletion in exon 1 of Cars2 gene containing a translation initiating codon. (J:254717)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cars2 Mutation: 30 strains or lines available

References

• Original: J:254717 Akaike T, et al., Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics. Nat Commun. 2017 Oct 27;8(1):1177
• All: 1 reference(s)