Ttc21a^em1Fzh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ttc21a^em1Fzh
• Name: tetratricopeptide repeat domain 21A; endonuclease-mediated mutation 1, Feng Zhang
• MGI ID: MGI:6368822
• Synonyms: Ttc21a^mut
• Gene: Ttc21a Location: Chr9:119766672-119796859 bp, + strand Genetic Position: Chr9, 71.33 cM, cytoband F4
• Alliance: Ttc21a^em1Fzh page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a frameshift mutation (c.2534del) which is predicted to cause premature translational termination. RT-qPCR assays revealed that testicular mRNA expression is reduced to approximately 26% of that in wild-type controls. (J:279926)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ttc21a Mutation: 68 strains or lines available

References

• Original: J:279926 Liu W, et al., Bi-allelic Mutations in TTC21A Induce Asthenoteratospermia in Humans and Mice. Am J Hum Genet. 2019 Apr 4;104(4):738-748
• All: 1 reference(s)