Galnt2^tm1.2Mrl
Targeted Allele Detail

Summary

• Symbol: Galnt2^tm1.2Mrl
• Name: polypeptide N-acetylgalactosaminyltransferase 2; targeted mutation 1.2, Merck Research Laboratory
• MGI ID: MGI:6368825
• Gene: Galnt2 Location: Chr8:124958133-125072461 bp, + strand Genetic Position: Chr8, 72.52 cM, cytoband E2
• Alliance: Galnt2^tm1.2Mrl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251899
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 to 6 were floxed. Flp-mediated recombination removed the selection cassette. A constitutive KO allele has been generated after Cre-mediated recombination by crossing chimeras to a Cre-Deleter. See https://www.taconic.com/mouse-model/galnt2-ko-9639 for more information. (J:251899)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Galnt2 Mutation: 38 strains or lines available

References

• Original: J:251899 Khetarpal SA, et al., Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents. Cell Metab. 2016 Aug 9;24(2):234-45
• All: 2 reference(s)