Tbx6^em2Fzh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tbx6^em2Fzh
• Name: T-box 6; endonuclease-mediated mutation 2, Feng Zhang
• MGI ID: MGI:6368863
• Synonyms: Tbx6^mh, Tbx6(R1)
• Gene: Tbx6 Location: Chr7:126380655-126384720 bp, + strand Genetic Position: Chr7, 69.25 cM
• Alliance: Tbx6^em2Fzh page

Mutation origin

• Strain of Origin: FVB/NJ

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a short 3 bp + 5 bp deletion in the regulatory region of mouse Tbx6 gene. This mutation caused a mild-hypomorphic allele.

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx6 Mutation: 17 strains or lines available

References

• Original: J:271649 Yang N, et al., TBX6 compound inheritance leads to congenital vertebral malformations in humans and mice. Hum Mol Genet. 2019 Feb 15;28(4):539-547
• All: 1 reference(s)