Ccdc51^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Ccdc51^tm1.1Geno
• Name: coiled-coil domain containing 51; targeted mutation 1.1, Genoway
• MGI ID: MGI:6368872
• Synonyms: MITOK-knockout
• Gene: Ccdc51 Location: Chr9:108911561-108921557 bp, + strand Genetic Position: Chr9, 59.63 cM
• Alliance: Ccdc51^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279978
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 4, which contains most of the coding sequence, was deleted after Cre-mediated recombination of flanking loxP sites in the germline. Western blot analysis confirmed the absence of protein expression in liver mitochondria isolated from homozygous mutant mice. (J:279978)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccdc51 Mutation: 27 strains or lines available

References

• Original: J:279978 Paggio A, et al., Identification of an ATP-sensitive potassium channel in mitochondria. Nature. 2019 Aug;572(7771):609-613
• All: 1 reference(s)