Tppp2^em1Nju
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tppp2^em1Nju
• Name: tubulin polymerization-promoting protein family member 2; endonuclease-mediated mutation 1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:6368880
• Gene: Tppp2 Location: Chr14:52155887-52158161 bp, + strand Genetic Position: Chr14, 26.72 cM
• Alliance: Tppp2^em1Nju page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 1 deleted 62 bp. Western blot analysis confirmed the absence of protein expression in testes. Immunofluorescence confirmed the absence of protein expression in sperm. (J:279929)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tppp2 Mutation: 16 strains or lines available

References

• Original: J:279929 Zhu F, et al., Deficiency of TPPP2, a factor linked to oligoasthenozoospermia, causes subfertility in male mice. J Cell Mol Med. 2019 Apr;23(4):2583-2594
• All: 1 reference(s)