Dusp22^tm1Tht
Targeted Allele Detail

Summary

• Symbol: Dusp22^tm1Tht
• Name: dual specificity phosphatase 22; targeted mutation 1, Tse-Hua Tan
• MGI ID: MGI:6368881
• Synonyms: Jkap^-
• Gene: Dusp22 Location: Chr13:30844042-30895215 bp, + strand Genetic Position: Chr13, 13.26 cM
• Alliance: Dusp22^tm1Tht page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213253
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The mutation replaces all of exons 5 and 6 (cDNA positions 249495 and codon positions 64145) with a neomycin selection cassette. This results in a null for mRNA as assessed by Northern blot. (J:79283)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dusp22 Mutation: 12 strains or lines available

References

• Original: J:213253 Li JP, et al., The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck. Nat Commun. 2014;5:3618
• All: 2 reference(s)