Arf5^tm1.1Tsdk
Targeted Allele Detail

Summary

• Symbol: Arf5^tm1.1Tsdk
• Name: ARF GTPase 5; targeted mutation 1.1, Tetsushi Sadakata
• MGI ID: MGI:6369002
• Gene: Arf5 Location: Chr6:28423603-28426601 bp, + strand Genetic Position: Chr6, 11.99 cM
• Alliance: Arf5^tm1.1Tsdk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279779
• Parent Cell Line: B6-3i/HK3i (ES Cell)
• Strain of Origin: C57BL/6NJcl

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette and exon 3. (J:279779)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arf5 Mutation: 13 strains or lines available

References

• Original: J:279779 Hosoi N, et al., Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial Segments. J Neurosci. 2019 Aug 7;39(32):6339-6353
• All: 1 reference(s)