Toe1^em1Jgg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Toe1^em1Jgg
• Name: target of EGR1, member 1 (nuclear); endonuclease-mediated mutation 1, Joseph G Gleeson
• MGI ID: MGI:6369003
• Gene: Toe1 Location: Chr4:116661199-116664785 bp, - strand Genetic Position: Chr4, 53.33 cM, cytoband C7
• Alliance: Toe1^em1Jgg page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology inserted a single base A at position 116806688-89, generating a single base-pair frameshift mutation resulting in a null allele. (J:260125)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Toe1 Mutation: 20 strains or lines available

References

• Original: J:260125 Lardelli RM, et al., Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing. Nat Genet. 2017 Mar;49(3):457-464
• All: 1 reference(s)