Zfp418^em#Juli
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zfp418^em#Juli
• Name: zinc finger protein 418; endonuclease-mediated mutation, Junming Li
• MGI ID: MGI:6369036
• Synonyms: ZNF418-KO
• Gene: Zfp418 Location: Chr7:7174352-7186559 bp, + strand Genetic Position: Chr7, 4.16 cM
• Alliance: Zfp418^em#Juli page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR-targeting of exon 2 of Zfp418 gene generated mutations. Genotyping revealed the mutations comprised mostly deletions (2-12 bp), but also some insertions (2-3 bp). All mutations are in the target sequence. The pound (#) symbol is used for the pool of all alleles for this gene found in the knock-out founders. (J:251673)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp418 Mutation: 37 strains or lines available

References

• Original: J:251673 Pan L, et al., Zinc-finger protein 418 overexpression protects against cardiac hypertrophy and fibrosis. PLoS One. 2017;12(10):e0186635
• All: 1 reference(s)