Ormdl3em1Quli
Endonuclease-mediated Allele Detail
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Symbol: |
Ormdl3em1Quli |
Name: |
ORM1-like 3 (S. cerevisiae); endonuclease-mediated mutation 1, Qiji Liu |
MGI ID: |
MGI:6369059 |
Synonyms: |
Ormdl3- |
Gene: |
Ormdl3 Location: Chr11:98472120-98478071 bp, - strand Genetic Position: Chr11, 62.07 cM
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Alliance: |
Ormdl3em1Quli page
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Strain of Origin: |
Not Specified
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Allele Type: |
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Endonuclease-mediated (Null/knockout) |
Mutation: |
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Not Specified
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A TALEN mutagenesis was used to introduce a truncated mutation within the third exon of Ormdl3 gene. (J:251260)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | Not Specified | |
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Phenotypes: |
Affected Systems |
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hematopoietic system
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abnormal spleen morphology
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small spleen
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abnormal splenic cell ratio
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immune system
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√
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abnormal spleen morphology
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√
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small spleen
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√
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abnormal splenic cell ratio
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ormdl3 Mutation: |
10 strains or lines available
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Original: |
J:251260 Dang J, et al., ORMDL3 Facilitates the Survival of Splenic B Cells via an ATF6alpha-Endoplasmic Reticulum Stress-Beclin1 Autophagy Regulatory Pathway. J Immunol. 2017 Sep 1;199(5):1647-1659 |
All: |
2 reference(s) |
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