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Ormdl3em1Quli
Endonuclease-mediated Allele Detail
Summary
Symbol: Ormdl3em1Quli
Name: ORM1-like 3 (S. cerevisiae); endonuclease-mediated mutation 1, Qiji Liu
MGI ID: MGI:6369059
Synonyms: Ormdl3-
Gene: Ormdl3  Location: Chr11:98472120-98478071 bp, - strand  Genetic Position: Chr11, 62.07 cM
Alliance: Ormdl3em1Quli page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Not Specified
    A TALEN mutagenesis was used to introduce a truncated mutation within the third exon of Ormdl3 gene. (J:251260)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
Not Specified
 
Phenotypes:
Affected Systems
show or hide all annotated terms
 
hematopoietic system
abnormal spleen morphology
small spleen
abnormal splenic cell ratio
immune system
abnormal spleen morphology
small spleen
abnormal splenic cell ratio
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ormdl3 Mutation:  10 strains or lines available
References
Original:  J:251260 Dang J, et al., ORMDL3 Facilitates the Survival of Splenic B Cells via an ATF6alpha-Endoplasmic Reticulum Stress-Beclin1 Autophagy Regulatory Pathway. J Immunol. 2017 Sep 1;199(5):1647-1659
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory

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