Znrf1^tm1Lchs
Targeted Allele Detail

Summary

• Symbol: Znrf1^tm1Lchs
• Name: zinc and ring finger 1; targeted mutation 1, Li-Chung Hsu
• MGI ID: MGI:6369072
• Synonyms: Znrf1^F
• Gene: Znrf1 Location: Chr8:112262652-112352352 bp, + strand Genetic Position: Chr8, 57.98 cM
• Alliance: Znrf1^tm1Lchs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250572
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The allele was generated via two homologous recombination events in embryonic stem cells (ES cells) to insert two loxP sites into the first and third introns of the Znrf1 gene because of the long second intron. (J:250572)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Znrf1 Mutation: 48 strains or lines available

References

• Original: J:250572 Lee CY, et al., The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation. Nat Commun. 2017 Jun 08;8:15502
• All: 2 reference(s)