Timm50^em1Ywxu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Timm50^em1Ywxu
• Name: translocase of inner mitochondrial membrane 50; endonuclease-mediated mutation 1, Yawei Xu
• MGI ID: MGI:6369400
• Gene: Timm50 Location: Chr7:28004941-28011497 bp, - strand Genetic Position: Chr7, 16.67 cM, cytoband A3
• Alliance: Timm50^em1Ywxu page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology (oligo1: TAGGCCTTGGAGCCCC-CACGGT and oligo2: AAAC ACCGTGGGGGCTCCAAGG) generated a 22 bp deletion in exon 2 (line 33-3). Western blot analysis confirmed absence of protein expression in the heart. (J:280190)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Timm50 Mutation: 19 strains or lines available

References

• Original: J:280190 Tang K, et al., Translocase of Inner Membrane 50 Functions as a Novel Protective Regulator of Pathological Cardiac Hypertrophy. J Am Heart Assoc. 2017 Apr 21;6(4)
• All: 1 reference(s)