Rcn2^{tm1b(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Rcn2^{tm1b(KOMP)Wtsi}
• Name: reticulocalbin 2; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:6369411
• Gene: Rcn2 Location: Chr9:55949129-55966367 bp, + strand Genetic Position: Chr9, 30.13 cM, cytoband C
• Alliance: Rcn2^{tm1b(KOMP)Wtsi} page

Mutation origin

• Mutant Cell Line: EPD0104_3_B03
• Germline Transmission: Earliest citation of germline transmission: J:280163
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 55951941 of Chromosome 9 upstream of the critical exon 3 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon at position 55952869. The critical exon 3 is thus flanked by loxP sites. Cre expression in the germline deleted exon 3. (J:280163)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rcn2 Mutation: 20 strains or lines available

References

• Original: J:280163 Li J, et al., Loss of reticulocalbin 2 lowers blood pressure and restrains ANG II-induced hypertension in vivo. Am J Physiol Renal Physiol. 2019 Jun 1;316(6):F1141-F1150
• All: 1 reference(s)