Mir425^em1Nju
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mir425^em1Nju
• Name: microRNA 425; endonuclease-mediated mutation 1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:6369665
• Synonyms: Mir-425^low
• Gene: Mir425 Location: Chr9:108445976-108446060 bp, + strand Genetic Position: Chr9, 59.51 cM
• Alliance: Mir425^em1Nju page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a 248 bp deletion to produce a null allele. (J:280159)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir425 Mutation: 1 strain or line available

References

• Original: J:280159 Hu YB, et al., miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson's disease. Cell Death Dis. 2019 Aug 5;10(8):589
• All: 1 reference(s)