Sult4a1^em2Uab
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sult4a1^em2Uab
• Name: sulfotransferase family 4A, member 1; endonuclease-mediated mutation 2, University of Alabama
• MGI ID: MGI:6370021
• Synonyms: Sult4a1^{Exon3(delta12)}
• Gene: Sult4a1 Location: Chr15:83960298-83989955 bp, - strand Genetic Position: Chr15, 39.73 cM
• Alliance: Sult4a1^em2Uab page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 3 using sgRNA 5'-AGGTGGCTCTTGATGAGGCGGGG3' deleted 12 bp, disrupting the structure around the active site His111. Western blot analysis confirmed the absence of protein expression in the brain. (J:280143)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sult4a1 Mutation: 10 strains or lines available

References

• Original: J:280143 Garcia PL, et al., Generation and Characterization of SULT4A1 Mutant Mouse Models. Drug Metab Dispos. 2018 Jan;46(1):41-45
• All: 1 reference(s)