Slc12a8^em1Imai
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc12a8^em1Imai
• Name: solute carrier family 12 (potassium/chloride transporters), member 8; endonuclease-mediated mutation 1, Shin-ichiro Imai
• MGI ID: MGI:6370147
• Gene: Slc12a8 Location: Chr16:33337698-33484505 bp, + strand Genetic Position: Chr16, 24.12 cM
• Alliance: Slc12a8^em1Imai page

Mutation origin

• Strain of Origin: C57BL/6J x CBA

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting removed exon 4. Western blot analysis confirmed the absence of protein expression in jejunum, ileum, and pancreas. (J:280135)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc12a8 Mutation: 32 strains or lines available

References

• Original: J:280135 Grozio A, et al., Slc12a8 is a nicotinamide mononucleotide transporter. Nat Metab. 2019 Jan;1(1):47-57
• All: 1 reference(s)