Dapl1^em1Nju
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dapl1^em1Nju
• Name: death associated protein-like 1; endonuclease-mediated mutation 1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:6370165
• Gene: Dapl1 Location: Chr2:59314997-59335364 bp, + strand Genetic Position: Chr2, 33.81 cM, cytoband C3
• Alliance: Dapl1^em1Nju page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 2 deleted 104 bp comprising part of intron 1 and exon 2. Western blot analysis confirmed the absence of protein expression in retinal pigmented epithelial. (J:242244)

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dapl1 Mutation: 11 strains or lines available

References

• Original: J:242244 Ma X, et al., DAPL1, a susceptibility locus for age-related macular degeneration, acts as a novel suppressor of cell proliferation in the retinal pigment epithelium. Hum Mol Genet. 2017 May 01;26(9):1612-1621
• All: 1 reference(s)