Tg(tetO-Xbp1_is)#Pesch
Transgene Detail

Summary

• Symbol: Tg(tetO-Xbp1_is)#Pesch
• Name: transgene insertion, Philipp E Scherer
• MGI ID: MGI:6376136
• Synonyms: TRE-Xbp1s
• Transgene: Tg(tetO-Xbp1_is)#Pesch Location: unknown
• Alliance: Tg(tetO-Xbp1_is)#Pesch page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-Xbp1_is)#Pesch expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Xbp1 (MGI:98970)	Expresses the spliced Xbp1s form

• Mutation details: The mouse Xbp1 with 26 nucleotides excised generating the spliced form (Xbp1s) is under the control of the tetracycline response element (tetO). (J:194290)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:194290 Deng Y, et al., The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism. J Clin Invest. 2013 Jan 2;123(1):455-68
• All: 9 reference(s)