Scoc^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Scoc^em1(IMPC)J
• Name: short coiled-coil protein; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6376211
• Gene: Scoc Location: Chr8:84161121-84185055 bp, - strand Genetic Position: Chr8, 40.22 cM
• Alliance: Scoc^em1(IMPC)J page
• IMPC: Scoc gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences CTAGCCTGGGAACAAGTGAG and ACTCTCCATGCTTTACTGCT, which resulted in a 3865 bp deletion beginning at Chromosome 8 position 83,434,286 bp and ending after 83,438,150 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001247660 through ENSMUSE00001393187 (exons 2-4) and 2163 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 26 and early truncation 16 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Scoc Mutation: 12 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)