Creg2^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Creg2^em1(IMPC)J
• Name: cellular repressor of E1A-stimulated genes 2; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6376217
• Gene: Creg2 Location: Chr1:39657574-39690350 bp, - strand Genetic Position: Chr1, 18.37 cM
• Alliance: Creg2^em1(IMPC)J page
• IMPC: Creg2 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences GTATTCATCTGAAAACGTGA and TATTCTGTCTGGAAGCTGAA, which resulted in a 575 bp deletion beginning at Chromosome 1 position 39,647,621 bp and ending after 39,648,195 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000356149 (exon 2) and 405 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 145 and early truncation 49 amino acids. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Creg2 Mutation: 18 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)