Ess2^tm1.1Nbioc
Targeted Allele Detail

Summary

• Symbol: Ess2^tm1.1Nbioc
• Name: ess-2 splicing factor; targeted mutation 1.1, Nihon University School of Medicine , Division of Biochemistry, Department of Biomedical Sciences
• MGI ID: MGI:6376226
• Synonyms: Dgcr14^{tm1c(KOMP)Nbioc}
• Gene: Ess2 Location: Chr16:17718573-17729212 bp, - strand Genetic Position: Chr16, 11.09 cM, cytoband B1-B3
• Alliance: Ess2^tm1.1Nbioc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:339504
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 17722696 of Chromosome 16 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 17726149. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. (J:339504)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ess2 Mutation: 29 strains or lines available

References

• Original: J:339504 Takada I, et al., Transcriptional coregulator Ess2 controls survival of post-thymic CD4(+) T cells through the Myc and IL-7 signaling pathways. J Biol Chem. 2022 Aug 3;298(9):102342
• All: 2 reference(s)