Ctf2^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ctf2^em1(IMPC)J
• Name: cardiotrophin 2; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6376255
• Gene: Ctf2 Location: Chr7:127318132-127324788 bp, - strand Genetic Position: Chr7, 69.69 cM
• Alliance: Ctf2^em1(IMPC)J page
• IMPC: Ctf2 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences GATGAGGAGGTCAGGAGTAA and CATGACACAATCAATCAGCC, which resulted in a 396 bp deletion beginning at Chromosome 7 position 127,723,008 bp and ending after 127,723,403 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000492582 (exon 2) and 256 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 8 and early truncation 6 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ctf2 Mutation: 14 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)