Dok3^tm1Kplm
Targeted Allele Detail

Summary

• Symbol: Dok3^tm1Kplm
• Name: docking protein 3; targeted mutation 1, Kong-Peng Lam
• MGI ID: MGI:6376621
• Synonyms: Dok-3^-
• Gene: Dok3 Location: Chr13:55671044-55677109 bp, - strand Genetic Position: Chr13, 30.06 cM
• Alliance: Dok3^tm1Kplm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:280795
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and part of exon 2 were replaced with a neomycin resistance cassette. Western blot analysis confirmed no full-length or truncated protein in splenic whole cell lysates. (J:280795)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dok3 Mutation: 18 strains or lines available

References

• Original: J:280795 Ng CH, et al., Dok-3 plays a nonredundant role in negative regulation of B-cell activation. Blood. 2007 Jul 1;110(1):259-66
• All: 5 reference(s)