Gt(ROSA)26Sor^{tm1(CAG-PTPN1,-EGFP)Mtr}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-PTPN1,-EGFP)Mtr}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Michel L Tremblay
• MGI ID: MGI:6378624
• Synonyms: R26^PTPN1
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-PTPN1,-EGFP)Mtr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231906
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Epitope tag, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-PTPN1,-EGFP)Mtr} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PTPN1 (5770)

  Ptpn1

  (MGI:97805)

• Mutation details: A construct containing a pCAGG promoter, a loxP flanked beta-Geo STOP cassette, a 3X-FLAG-tagged human PTPN1, IRES sequence, and EGFP was inserted into the locus. The inserted mouse gene and the reporter gene will only be expressed after removal of the STOP cassette through cre-mediated recombination. (J:231906)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:231906 Labbe DP, et al., PTP1B Deficiency Enables the Ability of a High-Fat Diet to Drive the Invasive Character of PTEN-Deficient Prostate Cancers. Cancer Res. 2016 Jun 1;76(11):3130-5
• All: 1 reference(s)