Rest^tm1.1Bban
Targeted Allele Detail

Summary

• Symbol: Rest^tm1.1Bban
• Name: RE1-silencing transcription factor; targeted mutation 1.1, Botond Banfi
• MGI ID: MGI:6378685
• Synonyms: Rest^flEx4
• Gene: Rest Location: Chr5:77413338-77434279 bp, + strand Genetic Position: Chr5, 41.61 cM
• Alliance: Rest^tm1.1Bban page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265659
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and a frt-flanked neomycin resistance gene were inserted upstream of exon 4 and a second loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette leaving exon 4 floxed. (J:265659)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rest Mutation: 96 strains or lines available

References

• Original: J:265659 Nakano Y, et al., Defects in the Alternative Splicing-Dependent Regulation of REST Cause Deafness. Cell. 2018 Jul 26;174(3):536-548.e21
• All: 1 reference(s)