Sirt3^tm1.2Auw
Targeted Allele Detail

Summary

• Symbol: Sirt3^tm1.2Auw
• Name: sirtuin 3; targeted mutation 1.2, Johan Auwerx
• MGI ID: MGI:6378760
• Synonyms: Sirt3^-
• Gene: Sirt3 Location: Chr7:140443579-140462222 bp, - strand Genetic Position: Chr7, 86.07 cM, cytoband F4
• Alliance: Sirt3^tm1.2Auw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:281453
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Exons 2-3 were deleted after Cre-mediated recombination of flanking loxP sites in the germline. (J:281453)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sirt3 Mutation: 32 strains or lines available

References

• Original: J:281453 Winnik S, et al., Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development. Basic Res Cardiol. 2014 Jan;109(1):399
• All: 5 reference(s)